CYM 5442
2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
CAS: 1094042-01-9
Molecular Formula: C23H27N3O4
CYM 5442 - Names and Identifiers
CYM 5442 - Physico-chemical Properties
| Molecular Formula | C23H27N3O4 |
| Molar Mass | 409.48 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Boling Point | 617.5±65.0 °C(Predicted) |
| Solubility | DMSO: >5mg/mL |
| pKa | 14.73±0.10(Predicted) |
| Storage Condition | -20°C |
| In vitro study | CYM-5442 is a chemical optimization agent of CYM-5181. CYM-5442 interacts with S1P 1 via a binding pocket structure, which is the arginine residue at position 120 and the glutamic acid residue at position 121 of S1P 1, this binding pocket is necessary for high affinity binding of S1P and receptor activation. |
| In vivo study | CYM-5442 is a complete agonist that can induce and maintain S1P1 dependent lymphopenia, and can reduce the B lymphocytes and T lymphocytes of the control group by 65% and 85% respectively. The induction of lymphopenia by CYM-5442 is related to the dose and time and requires a serum concentration in the range of 50 nM. Furthermore the CYM-5442 induced lymphopenia can be reversed by W146 or after the agonist is metabolically cleared. Pharmacokinetic studies in mice also showed a significant distribution of CYM-5442 in central nervous tissue. |
CYM 5442 - Risk and Safety
| WGK Germany | 3 |
CYM 5442 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.442 ml | 12.211 ml | 24.421 ml |
| 5 mM | 0.488 ml | 2.442 ml | 4.884 ml |
| 10 mM | 0.244 ml | 1.221 ml | 2.442 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.488 ml |
Last Update：2024-01-02 23:10:35
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View History
CYM 5442
Acetate) Adduct
bisphenol A diglycidyl ether polymer
39166-57-9
51186-58-4
UVA PLUS
草酸钙
2-CHLOROPROPYL PHENYL ETHER
中国白
6醇
Acetate) Adduct
bisphenol A diglycidyl ether polymer
39166-57-9
51186-58-4
UVA PLUS
草酸钙
2-CHLOROPROPYL PHENYL ETHER
中国白
6醇